The tumor was classified as TNM Stage IIB, grade 3BRCA1 analysis revealed that the cell line is homozygous for the BRCA1 5382C mutation, whereas the lymphoblastoid cell line derived from the same patient is heterozygous for the same mutationThis mutation was present in two other family members; an identical sister also developed breast cancerThe cell line has an acquired mutation of TP53 with wild-type allele loss; an acquired homozygous deletion of the PTEN gene, and loss of heterozygosity at multiple loci known to be involved in the pathogenesis of breast cancerThe cells are negative for expression of Her2-neu and for expression of p53.HCC1937 is positive for the epithelial cell specific marker Epithelial Glycoprotein 2 (EGP2) and for cytokeratin 19The cells are negative for expression of estrogen receptor (ER) and progesterone receptor (PR)An EBV transformed lymphoblastoid cell line (HCC1937BL) from the same patient is available.
种属来源: | 人 |
---|---|
组织来源: | 乳腺 |
疾病类型: | 乳腺癌 |
细胞贴壁类型: | 贴壁 |
细胞形态: | 上皮样 |
细胞数: | 30-50代 |
培养基: | RPMI-1640 |
血清: | FBS |
其他培养添加物: | - |
消化液: | KGY0012 |
成瘤性: | - |
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