简介

The cell population has been characterized as highly undifferentiated and of the granulocytic series.Studies conducted by Anderson, et al., on the surface membrane properties led to the conclusion that the K-562 was a human erythroleukemia line.K-562 blasts are multipotential, hematopoietic malignant cells that spontaneously differentiate into recognizable progenitors of the erythrocytic, granulocytic and monocytic series.The effect of inducers on sublines derived from the original K-562 cell line have been reviewed by Koeffler and Golde.Karyological studies on various K-562 sublines have been classified into three groups (A,B,C) by Dimery, et al.The strain most closely resembles the B population. Occurrence of the Philadelphia chromosome, however, was of much lower frequency; none detected in 15 metaphases examined.The line is EBNA negative.

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