EndotoxinOUT? was designed for the rapid removal of endotoxins and pyrogens (LPS, lipopolysaccharides) from nucleic acid (DNA) samples. EndotoxinOUT? is an ideal product for the cleanup of buffers, cell culture media, protein solutions, nucleic acid (DNA) samples and pharmacological components. EndotoxinOUT? consists of 6% cross-linked agarose covalently linked to polymyxin B to bind and remove harmful pyrogens from a solution. Polymyxin B is a family, polymyxin B1 and B2, of antibiotics that bind to the negatively charged site of the lipid A portion of the bacterial lipopolysaccharide layer, neutralizing the endotoxic activity. The covalently coupled agarose and polymyxin B is a stable matrix that resists leaching
Application for cleanup of buffers, cell culture media, protein solutions, DNA samples & pharmacological components, rapid 99.95% removal of endotoxins & pyrogens from samples.
Capacity | 9,995 endotoxin units (EU) removed by 1 ml resin from 5 ml test containing 10,000 EU |
Bead structure | Polymyxin B Sulfate immobilized on 6% cross-linked agarose |
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