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VRK1 is a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. VRK1 is widely expressed in human tissues and actively dividing cells, such as those in testis, leukocytes, fetal liver and carcinomas. VRK1 regulate cell proliferation and phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. The spinal muscular atrophy with pontocerebellar hypoplasia is caused by a mutation in the VRK1 gene.
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
PRECISIO 为以下机构的注册商标: Sigma-Aldrich Co. LLC
recombinant | expressed in baculovirus infected Sf9 cells |
grade | PRECISIO® Kinase |
assay | ≥70% (SDS-PAGE) |
form | buffered aqueous glycerol solution |
activity | 1.7-2.3 nmol/min·mg |
mol wt | mol wt ~71 kDa |
NCBI accession no. | NM_003384 |
shipped in | dry ice |
storage temp. | ?70°C |
Gene Information | human ... VRK1(7443) |
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