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TTBK2 (70-538), active, GST tagged from mouse PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

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号:SRP5216-10UG

牌:Sigma 西格玛

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别名: TTBK1 TTBK TTK mKIAA0847

产品名称

General description

TTBK2 or tau tubulin kinase 2 is a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. TTBK2 is a member of the casein kinase (CK1) group of eukaryotic protein kinases that is involved in tau phosphorylation and aggregation. Mutations in TTBK2 cause spinocerebellar ataxia type 11 (SCA11) (a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem).

Preparation Note

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

Physical form

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

法律信息

PRECISIO 为以下机构的注册商标: Sigma-Aldrich Co. LLC


性质

recombinant   expressed in baculovirus infected Sf9 cells
grade   PRECISIO® Kinase
assay   ≥70% (SDS-PAGE)
form   buffered aqueous glycerol solution
activity   315-426 nmol/min·mg
mol wt   mol wt ~88 kDa
NCBI accession no.   NM_080788
shipped in   dry ice
storage temp.   ?70°C
Gene Information   mouse ... Ttbk2(140810)

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