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TRKC is a member of the TRK family of tyrosine kinase receptors and is the high affinity catalytic receptor for the neurotrophin NT-3 (neurotrophin-3). TRKC mediates the multiple cellular effects of the NT-3 neurotrophic factor, which includes neuronal differentiation and survival. TRKC has been implicated in insulin signaling pathway through interactions with the MUSK protein receptor and the VEGF receptor. Mutations in the TRKC gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers.
Supplied in 50 mM sodium phosphate, pH 7.0, with 150 mM imidazole, 0.1 mM PMSF, 2 mM DTT, and 25% glycerol.
PRECISIO 为以下机构的注册商标: Sigma-Aldrich Co. LLC
recombinant | expressed in baculovirus infected Sf9 cells |
grade | PRECISIO® Kinase |
assay | ≥70% (SDS-PAGE) |
form | buffered aqueous glycerol solution |
activity | 20-28 nmol/min·mg |
mol wt | mol wt ~38 kDa |
shipped in | dry ice |
storage temp. | ?70°C |
Gene Information | human ... NTRK3(4916) |
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