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Popular Documents: Datasheet (PDF)
TLK1 or tousled-like kinase 1 is a nuclear serine/threonine kinase that is potentially involved in the regulation of chromatin assembly. TLK1 is first described in Arabidopsis. TLK1 is a novel target of the DNA damage checkpoint that is rapidly inactivated upon exposure to ionizing radiation (IR) and the inactivation is directly mediated by the S-phase DNA damage checkpoint. The suppression of TLK1 activity after double-strand breaks in the DNA, replication blockade, or low doses of ultraviolet irradiation requires ATM, NBS and CHK1.
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
PRECISIO 为以下机构的注册商标： Sigma-Aldrich Co. LLC
| recombinant | expressed in baculovirus infected Sf9 cells |
| grade | PRECISIO® Kinase |
| assay | ≥70% (SDS-PAGE) |
| form | buffered aqueous glycerol solution |
| activity | 5.3-7.1 nmol/min·mg |
| mol wt | mol wt ~135 kDa |
| NCBI accession no. | NM_012290 |
| shipped in | dry ice |
| storage temp. | ?70°C |
| Gene Information | human ... TLK1(9874) |
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