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TGFbR2 is a member of the TGFb receptor subfamily and is a ser/thr protein kinase. TGFbR2-induced protein phosphorylation plays a key role in signal transduction that leads to mitogenic responses. The TGFbR2 receptor transmits signals from the cell surface to the nucleus and provides instructions for making transforming growth factor (TGF)-beta type II receptor. Mutations in TGFbR2 gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors.
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
PRECISIO 为以下机构的注册商标: Sigma-Aldrich Co. LLC
recombinant | expressed in baculovirus infected Sf9 cells |
grade | PRECISIO® Kinase |
assay | ≥70% (SDS-PAGE) |
form | buffered aqueous glycerol solution |
activity | 6-8 nmol/min·mg |
mol wt | mol wt ~68 kDa |
shipped in | dry ice |
storage temp. | ?70°C |
Gene Information | human ... TGFBR2(7048) |
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