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Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
PKCζ (protein kinase C ζ) is a atypical PKC and works independent of Ca2+ and diacylglycerol. It is involved in MAPK (mitogen-activated protein kinase)-induced nuclear factor κ B activation. It also stabilizes DNA mismatch-repair proteins, participates in laeukemic cell differentiation, cell migration and chemotaxis. PKCζ have tumour suppressor as well as oncogenic properties. Upregulation of PKCζ causes apoptosis in ovarian carcinoma cells. On the other hand, absence of PKCζ decreases tumorigenic activity in a colon cancer mouse model.
PRECISIO 为以下机构的注册商标: Sigma-Aldrich Co. LLC
recombinant | expressed in baculovirus infected Sf9 cells |
grade | PRECISIO® Kinase |
assay | ≥70% (SDS-PAGE) |
form | buffered aqueous glycerol solution |
activity | 97-131 nmol/min·mg |
mol wt | mol wt ~93 kDa |
shipped in | dry ice |
storage temp. | ?70°C |
Gene Information | human ... PRKCZ(5590) |
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