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NUAK1 or SNF1/AMP kinase-related kinase (SNARK) is a member of the NUAK family of SNF1-like kinase 1 that is also known as AMPK-related protein kinase 5 (ARK5). ARK5 is a tumor cell survival factor that is activated by AKT and acts as an ATM kinase under conditions of nutrient starvation. NUAK1 is highly expressed in heart and brain, and at lower levels in skeletal muscle, kidney, ovary, placenta, lung, and liver. NUAK1 is involved in tolerance to glucose starvation and suppresses Fas-induced apoptosis by phosphorylation of CASP6, thus suppressing the activation of the caspase and the subsequent cleavage of CFLAR.
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
PRECISIO 为以下机构的注册商标: Sigma-Aldrich Co. LLC
recombinant | expressed in baculovirus infected Sf9 cells |
grade | PRECISIO® Kinase |
assay | ≥70% (SDS-PAGE) |
form | buffered aqueous glycerol solution |
activity | 42-58 nmol/min·mg |
mol wt | mol wt ~122 kDa |
NCBI accession no. | NM_014840 |
shipped in | dry ice |
storage temp. | ?70°C |
Gene Information | human ... NUAK1(9891) |
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