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NEK6 is a serine/threonine kinase that is a member of the Nek family of protein kinases that share an amino-terminal catalytic domain related to NIMA family. NEK6 is a nuclear and cytoplasmic kinase that is required for mitotic progression of human cells. NEK6 is phosphorylated and activated during M phase of the cell cycle.Inhibition of NEK6 function by either overexpression of an inactive NEK6 mutant or elimination of endogenous NEK6 by siRNA arrests cells in M phase and triggers apoptosis.
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
PRECISIO 为以下机构的注册商标: Sigma-Aldrich Co. LLC
recombinant | expressed in baculovirus infected Sf9 cells |
grade | PRECISIO® Kinase |
assay | ≥70% (SDS-PAGE) |
form | buffered aqueous glycerol solution |
activity | 114-154 nmol/min·mg |
mol wt | mol wt ~63 kDa |
shipped in | dry ice |
storage temp. | ?70°C |
Gene Information | human ... NEK6(10783) |
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