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Popular Documents: Datasheet (PDF)
MEKK6 or MAP3K6 (mitogen-activated protein kinase kinase kinase 6) is a member of the serine/threonine protein kinase family. MEKK6 was identified by its interaction with MAP3K5/ASK, a protein kinase and an activator of c-Jun kinase (MAPK7/JNK) and MAPK14/p38 kinase. MEKK6 cascades relay signals from the cell surface to the nucleus which result in gene transcription. MEKK6 activates the JNK and p38 pathway and induces apoptosis when overexpressed in stably transfected cells. MEKK6 transcript is expressed in several tissues, with the highest expression in heart and skeletal muscle.
After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.
Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
PRECISIO is a registered trademark of Sigma-Aldrich Co. LLC
| recombinant | expressed in baculovirus infected Sf9 cells |
| grade | PRECISIO® |
| assay | ≥70% (SDS-PAGE) |
| form | buffered aqueous glycerol solution |
| activity | 8-12 nmol/min·mg |
| mol wt | mol wt ~67 kDa |
| NCBI accession no. | NM_004672 |
| shipped in | dry ice |
| storage temp. | ?70°C |
| Gene Information | human ... MAP3K6(9064) |
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