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Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
LYN (proto-oncogene) belongs to the src family of tyrosine kinases. It controls cancer cell growth, migration, invasion and survival. Upregulation of LYN is associated with shorter overall survival in breast cancer. LYN shows anti- or pro-apoptotic effects. It can enhance AKT (v-akt murine thymoma viral oncogene homolog) phosphorylation or suppress AKT activation. It is also responisble for activation of p58 PI3K (phosphatidylinositol-4,5
PRECISIO 为以下机构的注册商标: Sigma-Aldrich Co. LLC
recombinant | expressed in baculovirus infected Sf9 cells |
grade | PRECISIO® Kinase |
assay | ≥70% (SDS-PAGE) |
form | buffered aqueous glycerol solution |
activity | 205-277 nmol/min·mg |
mol wt | mol wt ~85 kDa |
shipped in | dry ice |
storage temp. | ?70°C |
Gene Information | human ... LYN(4967) |
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