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Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
INSR (insulin receptor) belongs to the receptor tyrosine kinase family and is a cell surface receptor. Insulin binding to INSR results in autophosphorylation and increased catalytic activity. These events are important for downstream signalling. Insulin/INSR signaling is crucial in the central nervous system for controlling blood glucose levels, synaptic plasticity, dendritic growth, regulation of electrophysiological activity, astrocytes proliferation and neuronal cell death. Mutations in INSR are associated with hyperinsulinemic hypoglycemia syndrome.
PRECISIO 为以下机构的注册商标: Sigma-Aldrich Co. LLC
recombinant | expressed in baculovirus infected Sf9 cells |
grade | PRECISIO® Kinase |
assay | ≥70% (SDS-PAGE) |
form | buffered aqueous glycerol solution |
activity | 2281-3086 nmol/min·mg |
mol wt | mol wt ~70 kDa |
shipped in | dry ice |
storage temp. | ?70°C |
Gene Information | human ... INSR(3643) |
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