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Supplied in 50 mM Sodium Phosphate, pH 7.0, with 150 mM imidazole, 0.1 mM PMSF, 0.2 mM DTT, and 25% glycerol.
IGF1R (insulin-like growth factor 1 receptor) is a transmembrane tyrosine kinase receptor that is activated by IGF1 (insulin-like growth factor 1) as well as IGF2. IGF1R plays a key role in tumorigenesis. The IGF1R is implicated in several cancers, most notably breast cancer where it is highly overexpressed and causes disease progression and poor prognosis. In many instances, IGF1R overexpression allows cancerous cells to resist the cytotoxic properties of chemotheraputic drugs or radiotherapy.
PRECISIO 为以下机构的注册商标: Sigma-Aldrich Co. LLC
recombinant | expressed in baculovirus infected Sf9 cells |
grade | PRECISIO® Kinase |
assay | ≥70% (SDS-PAGE) |
form | buffered aqueous glycerol solution |
activity | 224-302 nmol/min·mg |
mol wt | mol wt ~53 kDa |
shipped in | dry ice |
storage temp. | ?70°C |
Gene Information | human ... IGF1R(3480) |
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