MDL number MFCD01634845
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Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
FES regulates the growth and differentiation of neurons, hematopoietic, vascular endothelial and epithelial cell lines. Inactivation of this gene leads to suppression of human renal carcinoma cell proliferation, and thus, might have potential as a therapeutic target. It is a highly regulated oncogene, and in transgenic mice, its up-regulation leads to tissue hyperplasia, hemangioma formation and oncogenic transformation of fibroblasts. It however, acts as a tumor suppressor in colorectal cancer (CRC), where it is inactivated due to promoter methylation.
FES is a protein-tyrosine kinase, which was first identified as a homolog of transforming oncogene in avian and feline retrovirus. It is a 93kDa protein, which is expressed in endothelial, epithelial, myeloid, vascular and neuronal cells.
PRECISIO 为以下机构的注册商标: Sigma-Aldrich Co. LLC
recombinant | expressed in baculovirus infected Sf9 cells |
grade | PRECISIO® Kinase |
assay | ≥70% (SDS-PAGE) |
form | buffered aqueous glycerol solution |
activity | 48-64 nmol/min·mg |
mol wt | mol wt ~125 kDa |
shipped in | dry ice |
storage temp. | ?70°C |
Gene Information | human ... FES(2242) |
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