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Popular Documents: Datasheet (PDF)
CDC7 is a cell division cycle 7 homolog protein that is critical for the G1/S transition and is also essential for initiation of DNA replication as cell division occurs. CDC7 is expressed in many normal tissues, but the overexpression of CDC7 may be associated with neoplastic transformation for some tumors and transformed cell lines. CDC7/DBF4 kinase promotes S phase by alleviating an inhibitory activity in Mcm4 that evolved to integrate several protein kinase.
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
PRECISIO 为以下机构的注册商标： Sigma-Aldrich Co. LLC
| recombinant | expressed in baculovirus infected Sf9 cells |
| grade | PRECISIO® Kinase |
| assay | ≥70% (SDS-PAGE) |
| form | buffered aqueous glycerol solution |
| activity | 7.2-9.8 nmol/min·mg |
| mol wt | mol wt ~125 kDa (DBF4) |
| mol wt ~94 kDa (CDC7) | |
| NCBI accession no. | NM_003503 |
| NM_006716 | |
| shipped in | dry ice |
| storage temp. | ?70°C |
| Gene Information | human ... CDC7(8317), DBF4(10926) |
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