Application

All Prestige Antibodies^®Powered by Atlas Antibodies is developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org). Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.

Features and Benefits

抗体生物保证
放心评估或选择我们的抗体。如果抗体在你的实验中不好用，我们会在信用体系内完成退换货流程。点击了解更多。

Immunogen

Arachidonate 15-lipoxygenase recombinant protein epitope signature tag (PrEST)

Linkage

Corresponding Antigen APREST72464.

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Biochem/physiol Actions

The gene ALOX15 encodes a non-heme iron-containing dioxygenase called as arachidonate 15-lipoxygenase. It encodes the type 1 isozyme of 15-Lipoxygenase. The enzyme catalyzes the oxygenation of free fatty acids and fatty acids bound to membrane phospholipids. The reaction converts arachidonic acid to 12- and 15-HETE (hydroxyeicosatetraenoic acid). The gene has been associated with the development of asthma, arthritis, and atherosclerosis. Polymorphism in this gene has been implicated as a determinant of bone mineral density in postmenopausal women and may serve as a marker for osteoporosis. The enzyme may play a role in inflammation.

General description

The gene ALOX15 (Arachidonate 15-lipoxygenase) is mapped to human chromosome 17p13.3.

法律信息

Prestige Antibodies 为以下机构的注册商标： Sigma-Aldrich Co. LLC