MDL number MFCD00165567
Popular Documents: Specification Sheet (PDF)
Lyophilized powder from 20 mM Tris-HCl, pH 7.4, containing 0.1 M NaCl
In addition, activated protein C has been shown to inhibit TNF-α induced expression of the inflammatory proteins VCAM, ICAM-I, and Ilk-8 in endothelial cells.
Protein C is a plasma, vitamin κ-dependent zymogen of a serine protease that can inhibit blood coagulation by inhibiting thrombin formation, selectively inactivating Factors Va and VIIIa. The Protein C anticoagulant pathway is triggered when thrombin binds to the endothelial cell proteoglycan, thrombomodulin. This complex, which cannot clot blood, is a potent activator of the protein C zymogen. Activation involves the release of a dodecapeptide from the N-terminal domain of the heavy chain. The activated Protein C (APC) then binds to protein S on cell surfaces and inactivates the coagulation factors Va and VIIIa by proteolysis. APC has also been shown to bind to receptors on the endothelium of large blood vessels.
Protein C is a plasma, vitamin κ-dependent zymogen of a serine protease that can inhibit blood coagulation by inhibiting thrombin formation, selectively inactivating Factors Va and VIIIa.
assay | ≥90% (SDS-PAGE) |
form | lyophilized powder |
mol wt | heavy chain mol wt 41 kDa |
light chain mol wt 21 kDa | |
solubility | H2O: soluble1 mg/mL |
storage temp. | ?20°C |
Gene Information | human ... PROC(5624) |
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