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Mouse Anti-Cytokeratin 17, clone E3

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货号：MAB1677

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, R ICC, IF, IHC, WB M Ascites Monoclonal Antibody
Description
Catalogue Number MAB1677
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Cytokeratin 17 Antibody, clone E3
Alternate Names
  • Keratin, type I cytoskeletal 17
  • Cytokeratin-17
  • CK-17
  • Keratin-17
  • K17
  • Type I keratin Ka17
References
Product Information
Format Ascites
Presentation Ascites with no preservatives.
Applications
Application Anti-Cytokeratin 17 Antibody, clone E3 is an antibody against Cytokeratin 17 for use in WB, IC, IH(P).
Key Applications
  • Immunocytochemistry
  • Immunofluorescence
  • Immunohistochemistry
  • Western Blotting
Application Notes Immunocytochemistry Analysis: A representative lot immunostained intermediate filaments in 1 % Triton X-100-permeabilized, 4% formaldehyde-fixed HeLa cells by indirect immunofluorescence (Troyanovsky, S.M., et al. (1989). J. Cell Sci. 93(Pt 3):419-426).

Immunofluorescence Analysis: A representative lot localized cytokeratin 17 immunoreactivity in cryosections from human salivary glands, urinary bladder, sebaceous gland and hair folliculus by indirect immunofluorescence (Troyanovsky, S.M., et al. (1989). J. Cell Sci. 93(Pt 3):419-426).

Immunohistochemistry Analysis: A representative lot immunostained newly regenerated hair follicles after wounding in 4% paraformaldehyde-fixed rat skin epidermal tissue expressing transfected hTERT (Jan, H.M., et al. (2012). Gene Ther. 19(1):86-93).

Western Blotting Analysis: A representative lot detected cytokeratin 17 in HeLa total cell lysate as well as in intermediate filaments/IF-enriched cytoskeletal fractions from HeLa cells, human bronchus tissue, Papilloma of the human mammary gland, and transitional cell papilloma of the human urinary bladder (Troyanovsky, S.M., et al. (1989). J. Cell Sci. 93(Pt 3):419-426).
Biological Information
Immunogen Cytoskeletal preparation from rat colon (Troyanovsky, S.M., et al. (1989). J. Cell Sci. 93(Pt 3):419-426).
Clone E3
Host Mouse
Specificity Clone E3 immunostained intermediate filaments in HeLa cells by indirect immunofluorescence (Troyanovsky, S.M., et al. (1989). J. Cell Sci. 93(Pt 3):419-426).
Isotype IgG2bκ
Species Reactivity
  • Human
  • Rat
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary KRT17 encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex.
Gene Symbol
  • Krt17
  • Ka17
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q6IFU8 # May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial stem cells. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair (By similarity).
SIZE: 433 amino acids; 48123 Da
SUBUNIT: Heterodimer of a type I and a type II keratin. KRT17 associates with KRT6 isomers. Interacts with TRADD and SFN (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
TISSUE SPECIFICITY: Expressed in the outer root sheath and medulla region of hair follicle specifically from eyebrow and beard, digital pulp, nail matrix and nail bed epithelium, mucosal stratified squamous epithelia and in basal cells of oral epithelium, palmoplantar epidermis and sweat and mammary glands. Also expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of sebaceous gland and in exocervix (at protein level).
SIMILARITY: SwissProt: Q6IFU8 ## Belongs to the intermediate filament family.
Molecular Weight 48.11/48.12 kDa (human/rat) calculated. ~47 kDa reported (Troyanovsky, S.M., et al. (1989). J. Cell Sci. 93(Pt 3):419-426).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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