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Rb X Dishevelled-1

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货号：AB5970

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number AB5970
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Dishevelled-1 Antibody
Alternate Names
  • DSH
  • DVL1
  • DSH Homolog 1
Background Information DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation. The protein acts as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 mutation is likely responsible for transformation in neuroblastomas, and the Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1 gene, thus DVL1 maybe important in these diseases as well.
References
Product Information
Format Affinity Purified
Control
  • SK-N-SH (neuroblastoma) whole cell lysates
Presentation Liquid in PBS, pH 7.4, containing 0.01M sodium azide.
Applications
Application Anti-Dishevelled-1 Antibody is an antibody against Dishevelled-1 for use in WB.
Key Applications
  • Western Blotting
Application Notes Western blot: 1:500 using ECL. The antibody reacts with a protein of ~85kDa. Dilute antibody in 50 mM PBS, pH 7.4 containing 1.5% sodium chloride and 1% normal animal serum (same species as the host of the secondary antibody).

Optimal working dilutions must be determined by end user.
Biological Information
Immunogen Synthetic peptide corresponding to amino acids 557-571 of human dishevelled-1 protein.
Host Rabbit
Specificity Dishevelled-1 protein (dvl-1). By Western blot the antibody shows no cross reactivity with recombinant dishevelled -2 or dishevelled -3 protein Pre-adsorption of the antibody with the immunogen peptide completely abolishes its reactivity by Western blot against dishevelled -1 protein.
Species Reactivity
  • Human
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development.
Gene Symbol
  • DVL1
  • Dishevelled-1
  • DVL
  • MGC54245
UniProt Number
UniProt Summary FUNCTION: SwissProt: O14640 # May play a role in the signal transduction pathway mediated by multiple Wnt genes.
SIZE: 695 amino acids; 75187 Da
SUBUNIT: Interacts with BRD7 and INVS. Interacts through its PDZ domain with the C-terminal regions of VANGL1, VANGL2 and CCDC88C/DAPLE.
PTM: Ubiquitinated, leading to its subsequent degradation by the ubiquitin-proteasome. The interaction with INVS is required for ubiquitination.
SIMILARITY: SwissProt: O14640 ## Belongs to the DSH family. & Contains 1 DEP domain. & Contains 1 DIX domain. & Contains 1 PDZ (DHR) domain.
Stem Cell Type
  • Neural Stem Cells
  • Hematopoietic Stem Cells
Molecular Weight 85 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -20°C in undiluted aliquots (not less than 10 μL) for up to 6 months. Avoid repeated freeze/thaw cycles. The use of high quality antiserum-grade plastic or glass is recommended.
Packaging Information
Material Size 50 µL
Transport Information
Supplemental Information
Specifications

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