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Ms X 1-CYS Peroxiredoxin

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货号：MAB3478

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, R WB, ICC, IHC M Ascites Monoclonal Antibody
Description
Catalogue Number MAB3478
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-1-cys Peroxiredoxin Antibody, clone 8H11
Alternate Names
  • aiPLA2
  • Peroxiredoxin 6
  • Non-selenium Glutathione Peroxidase
Background Information 1-Cys-Peroxiredoxin is a cytosolic protein that is involved in the regulation of cellular redox potential. 1-Cys peroxiredoxin is a bifunctional enzyme with glutathione peroxidase and phospholipase A2 activities (Chen, 2000). It can reduce hydrogen peroxide, short chain fatty acids, and phospholipid hydroperoxides and is believed to play a role in phospholipid turnover as well as in the protection against oxidative injury.
References
Product Information
Format Ascites
Presentation Ascites fluid. Liquid.
Applications
Application Detect 1-cys Peroxiredoxin using this Anti-1-cys Peroxiredoxin Antibody, clone 8H11 validated for use in WB, IC, IH.
Key Applications
  • Western Blotting
  • Immunocytochemistry
  • Immunohistochemistry
Application Notes Western blot on rat lung lysate (24 kDa) or recombinant human protein.

Immunohistochemistry on 4% paraformaldehyde fixed rat lung tissue.

Immunocytochemistry on rat type II alveolar epithelial cells.

Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen Recombinant human 1-Cys peroxiredoxin.
Clone 8H11
Host Mouse
Specificity 1-Cys-Peroxiredoxin (Prx VI).
Isotype IgM
Species Reactivity
  • Human
  • Rat
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.
Gene Symbol
  • PRDX6
  • p29
  • Peroxiredoxin-6
  • MGC46173
  • PRX
  • aiPLA2
  • AOP2
  • 1-Cys
  • KIAA0106
  • NSGPx
  • EC 1.11.1.15
  • EC 3.1.1.-
  • EC 1.11.1.7
UniProt Number
UniProt Summary FUNCTION: SwissProt: P30041 # Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.
SIZE: 224 amino acids; 25035 Da
SUBUNIT: Homotetramer. May interact with HTR2A (By similarity). Interacts with STH.
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Lysosome (By similarity). Cytoplasmic vesicle (By similarity). Note=And also found in lung secretory organelles (By similarity).
SIMILARITY: SwissProt: P30041 ## Belongs to the ahpC/TSA family. Rehydrin subfamily.
MISCELLANEOUS: The active site is the redox-active Cys-47 oxidized to Cys-SOH. Cys-SOH may rapidly react with a Cys-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin. & Irreversibly inactivated by overoxidation of Cys-47 (to Cys-SO(3)H) upon oxidative stress.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -20°C in undiluted aliquots up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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