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Ms X c-myc

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货号：MAB8864

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H FC, WB, IHC, IH(P) M Purified Monoclonal Antibody
Description
Catalogue Number MAB8864
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-c-myc Antibody, clone 9E10.3
References
Product Information
Format Purified
Control
  • POSITIVE CONTROL:

    HL-60 cells. Breast tumors.
Presentation Liquid in 10 mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.
Applications
Application Detect c-myc also known as Proto-oncogene c-Myc with Anti-c-myc Antibody, clone 9E10.3 (Mouse Monoclonal Antibody), that has been demonstrated to work in FC, WB, IHC, IHC(P).
Key Applications
  • Flow Cytometry
  • Western Blotting
  • Immunohistochemistry
  • Immunohistochemistry (Paraffin)
Application Notes Flow Cytometry

Western Blot: 1:200-1:400

Electron Microscopy

Immunofluorescence (Predominantly nuclear with some cytoplasmic)

Immunohistology (frozen & formalin/paraffin): 1:50-1:100 (30-60 mins. at RT)

Optimal working dilutions must be determined by end user.
Biological Information
Immunogen A synthetic peptide, corresponding to aa 408-439 (AEEQKLISEEDLLRKRREQLKHKLEQLRNSCA) from C-terminus of human c-myc, coupled to KLH.
Epitope a.a. 410-419
Clone 9E10.3
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity MAB8864 recognizes an oncoprotein of 64-67 kDa, identified as c-myc. Its eptiope spans between aa 410-419 (EQKLISEEDL) which is a specific portion of an alpha helical region of human c-myc protein. MAB8864 shows no cross-reaction with v-myc. c-myc is involved in the control of cell proliferation and differentiation and is amplified and/or overexpressed in a variety of tumors.
Isotype IgG1κ
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.
Gene Symbol
  • MYC
  • C-MYC
  • c-Myc
Non-Reactive Species
  • Chicken
  • Mouse
  • Rat
UniProt Number
UniProt Summary FUNCTION: SwissProt: P01106 # Participates in the regulation of gene transcription. Binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes.
SIZE: 439 amino acids; 48804 Da
SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with JARID1A and JARID1B.
SUBCELLULAR LOCATION: Nucleus.
PTM: Phosphorylated by PRKDC.
DISEASE: SwissProt: P01106 # Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors. & A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1.
SIMILARITY: SwissProt: P01106 ## Contains 1 basic helix-loop-helix (bHLH) domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at 2-8°C for up to 12 months.
Packaging Information
Material Size 50 µg
Transport Information
Supplemental Information
Specifications

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