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Ms X Estrogen Receptor

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货号：MAB443

品牌：Millipore 密理博

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Replacement Information

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
B, Ch, H, M EMSA, IP, WB, IHC M Ascites Monoclonal Antibody
Description
Catalogue Number MAB443
Replaces 04-227
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Estrogen Receptor Antibody, clone AER304
Alternate Names
  • ER
References
Product Information
Format Ascites
Presentation Liquid
Applications
Application Anti-Estrogen Receptor Antibody, clone AER304 is a Mouse Monoclonal Antibody for detection of Estrogen Receptor also known as ER & has been validated in EMSA, IP, WB & IHC.
Key Applications
  • Electrophoretic Mobility Shift Assay
  • Immunoprecipitation
  • Western Blotting
  • Immunohistochemistry
Application Notes Western blot (human)

Immunoprecipitation (human)

Immunohistochemistry (mouse)

Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen Bovine estrogen receptor.
Epitope a.a. 120-170
Clone AER304
Host Mouse
Specificity Estrogen receptor 67kD hormone binding subunit. Epitope localized between aa 120-170.
Isotype IgG1
Species Reactivity
  • Bovine
  • Chicken
  • Human
  • Mouse
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.
Gene Symbol
  • ESR1
  • ER-alpha
  • ESR
  • Era
  • ER
  • NR3A1
  • ESRA
  • DKFZp686N23123
UniProt Number
UniProt Summary FUNCTION: SwissProt: P03372 # Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.
SIZE: 595 amino acids; 66216 Da
SUBUNIT: Binds DNA as a homodimer. Can form a heterodimer with ESR2. Interacts with NCOA3, NCOA5 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with NCOA7 in a ligand-inducible manner. Interacts with PHB2, PELP1 and UBE1C. Interacts with AKAP13. Interacts with CUEDC2. Interacts with JARID1A. Interacts with SMARD1. Interacts with SLC30A9 (By similarity). Interacts with HEXIM1 and MAP1S. Interacts with PBXIP1.
SUBCELLULAR LOCATION: Nucleus.
DOMAIN: SwissProt: P03372 Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.
PTM: Phosphorylated by cyclin A/CDK2. Phosphorylation probably enhances transcriptional activity.
SIMILARITY: Belongs to the nuclear hormone receptor family. NR3 subfamily. & Contains 1 nuclear receptor DNA-binding domain.
MISCELLANEOUS: In the absence of ligand, steroid hormone receptors are thought to be weakly associated with nuclear components; hormone binding greatly increases receptor affinity. The hormone- receptor complex appears to recognize discrete DNA sequences upstream of transcriptional start sites.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -20°C in undiluted aliquots for up to one year. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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