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货号：MAB3752

品牌：Millipore 密理博

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Replacement Information

特卖

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, R IHC M Purified Monoclonal Antibody
Description
Catalogue Number MAB375-C
Replaces MAB375
Description Anti-Tau Antibody, clone Tau-2 (Ascites Free)
Alternate Names
  • Microtubule-associated protein tau
  • Neurofibrillary tangle protein
  • Paired helical filament-tau
  • PHF-tau
  • Tau
Background Information Microtubule-associated protein tau (UniProt P29172; also known as Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau) is encoded by the MAPT (also known as TAU) gene (Gene ID 281296) in bovine species. Extracellular plaque deposits composed of amyloid-β and intracellular neurofibrillary tangles (NFTs) composed of truncated and hyperphosphorylated tau are two neuropathological hallmarks of Alzheimer's disease (AD). Tau pathology (tauopathy) can cause toxicity when the brain is devoid of amyloid plaques, and tangle pathology correlates better with clinical dementia than amyloid pathology. Abnormal processing of tau by hyperphosphorylation and proteolytic truncation contribute to the toxicity of tau. Tau is known to be cleaved by various proteases, including caspases, calpains, cathepsins, thrombin, and puromycin-sensitive aminopeptidase, as well as the lysosomal cysteine proteinase asparagine endopeptidase (AEP). MAPK, GSK-3, and Cdk-5 are three known kinases that target various tau phosphorylation sites. Tau also undergoes other types of posttranslational modifications, including glycosylation, ubiquitination, glycation, polyamination, nitration, and lysine methylation, which are believed to be important for its non-pathological functions, including polymerization and stabilization of microtubules.
References
Product Information
Format Purified
Presentation Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Anti-Tau Antibody, clone Tau-2 (Ascites Free) is an antibody against Tau for use in Immunohistochemistry.
Key Applications
  • Immunohistochemistry
Application Notes Immunohistochemistry Analysis: A 1:5,000 dilution from a representative lot detected Tau in rat kidney tissue.
Biological Information
Immunogen Bovine Tau.
Clone Tau-2
Concentration Please refer to lot specific datasheet.
Host Mouse
Specificity Tau from bovine, feline and abnormal human tau in Alzheimer's disease.
Isotype IgG1κ
Species Reactivity
  • Human
  • Rat
Species Reactivity Note Human, Rat. Predicted to react with Bovine, Feline based on 100% sequence homology.
Antibody Type Monoclonal Antibody
Entrez Gene Number
Gene Symbol
  • MAPT
  • TAU
Purification Method Protein G Purified
UniProt Number
Molecular Weight 46 kDa calculated
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Immunohistochemistry in Alzheimer's diseased human cerebral cortex tissue.

Immunohistochemistry Analysis: A 1:5,000 dilution of this antibody detected Tau-positive plaques in Alzheimer's diseased human cerebral cortex tissue.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 μg
Transport Information
Supplemental Information
Specifications

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