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Anti-beta Arrestin 1, clone 3H11.2 (mouse monoclonal)

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货号：MAB2609

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB, IF M Purified Monoclonal Antibody
Description
Catalogue Number MAB2609
Description Anti-beta Arrestin 1 Antibody, clone 3H11.2
Alternate Names
  • Retinal S-antigen
  • Rod photoreceptor arrestin
  • S-antigen
  • retina and pineal gland (arrestin)
  • arrestin 1
  • retinal S-antigen (48 KDa protein)
Background Information The Arrestin family consists of four members: Arrestin 1 (visual Arrestin), Arrestin 2 (beta Arrestin 1), Arrestin 3 (beta Arrestin 2), and Arrestin 4 (cone Arrestin). While visual and cone Arrestins are found almost exclusively in the retina, beta Arrestins 1 and 2 are ubiquitously expressed. Beta Arrestins appear to act as negative regulators on G protein-coupled receptors, (Lefkowitz, 1998). Interaction with molecules such as clathrin, AP-2 and NSF directs the clathrin-mediated internalization of G-protein-coupled receptors. Interaction with molecules such as Src, Raf, Erk, ASK1 and JNK3 appears to regulate several pathways that result in the activation of MAP kinases, (Lin, 1998; Miller, 2001).
References
Product Information
Format Purified
Control
  • HEK293 cell lysate
Presentation Purified in PBS with 0.05% NaN3.
Applications
Application Anti-beta Arrestin 1 Antibody, clone 3H11.2 detects level of beta Arrestin 1 & has been published & validated for use in WB & IF.
Key Applications
  • Western Blotting
  • Immunofluorescence
Biological Information
Immunogen KLH conjugated synthetic peptide corresponding to amino acids 357-372 of human beta arrestin 1.
Epitope a.a. 357-372
Clone clone 3H11.2
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity Reacts with human beta-arrestin 1.
Isotype IgMκ
Species Reactivity
  • Human
Species Reactivity Note Reacts with human. Other species have not been tested.
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described, however, their exact functions are not known. [provided by RefSeq]
Gene Symbol
  • ARRESTIN
  • S-AG
  • S-arrestin
Purification Method Ammonium Sulfate Precipitation
UniProt Number
UniProt Summary FUNCTION: Regulates beta-adrenergic receptor function. Beta-arrestins seem to bind phosphorylated beta-adrenergic receptors, thereby causing a significant impairment of their capacity to activate G(S) proteins.
SEQUENCE SIMILARITIES: Belongs to the arrestin family.
Molecular Weight ~47 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated on a representative lot by Western blot in HEK293 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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