Anti-phospho-MEK4 (Ser257/Thr261)

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Anti-phospho-MEK4 (Ser257/Thr261)

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货号：07-857

品牌：Millipore 密理博

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H, M, R, B, Xn, Zebrafish	WB, PIA	Rb	Affinity Purified	Polyclonal Antibody

Description
Catalogue Number	ABS160
Replaces	07-857
Description	Anti-phospho-MKK4 Antibody (Ser257/Thr261)
Alternate Names	Dual specificity mitogen-activated protein kinase kinase 4 MAP kinase kinase 4 MAPKK 4 JNK-activating kinase 1 MAPK/ERK kinase 4 MEK 4 SAPK/ERK kinase 1 SEK1 Stress-activated protein kinase kinase 1 SAPK kinase 1 SAPKK-1 SAPKK1 c-Jun N-terminal kinase kinase 1 JNKK
Background Information	Also known as dual specificity mitogen-activated protein kinase kinase 4, JNK-activating kinase 1, and MAP/ERK kinase 4 among other names, MKK4 is protein kinase that plays a critical role in the MAP kinase signal transduction pathway and in stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling. MKK4 is required for maintenance of peripheral lymphoid homeostasis, and is involved in stress response and apoptosis. It also acts as a metastasis suppressor in certain cancers, such as prostate and ovarian cancer.

References

Product Information
Format	Affinity Purified
Control	Activated MKK4 (Cat. No. 14-377) alone, or with non phospho or phospho peptide
Presentation	Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Applications
Application	Detect the phospho-MKK4 (Ser257/Thr261) protein using this Anti-phospho-MKK4 (Ser257/Thr261) validated for use in WB & Peptide Inhibition Assay.
Key Applications	Western Blotting Peptide Inhibition Assay

Biological Information
Immunogen	KLH-conjugated linear peptide corresponding to human MKK4 phosphorylated at Ser257 and Thr261.
Epitope	Phosphorylated at Ser257 and Thr261
Host	Rabbit
Specificity	This antibody recognizes MKK4 phosphorylated at Ser257 and phosphorylated at Thr261.
Species Reactivity	Human Mouse Rat Bovine Xenopus Zebrafish
Species Reactivity Note	Demonstrated to react with Human. Predicted to react with Mouse, Rat, Bovine, Xenopus, and Zebrafish based on 100% sequence homology.
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NP_003001
Gene Symbol	MAP2K4 JNKK1 MEK4 MKK4 PRKMK4 SEK1 SERK1 SKK1
Purification Method	Affinity Purfied
UniProt Number	P45985
Molecular Weight	~64 kDa observed. The calculated molecular weight of MKK4 is 44 kDa, but the GST-tagged MKK4 protein used in this Western Blot is observed at ~64 kDa.

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blot in activated MKK4 (Cat. No. 14-377) alone, or with non phospho or phospho peptide. Western Blot Analysis: A 1:30,000 diluiton of this antibody detected phospho-MKK4 (Ser257/Thr261) in 500 ng of activated MKK4 recombinant protein. Peptide inhibition was observed with the addition of phospho peptides, but not with the addition of non-phospho peptides or antibody alone (500 ng of recombinant protein was loaded onto the SDS-PAGE gel. It is recommended for end-users to determine optimal antibody dilutions respective to the amount of test sample used.).
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Product Usage Statements

Quality Assurance

Evaluated by Western Blot in activated MKK4 (Cat. No. 14-377) alone, or with non phospho or phospho peptide.

Western Blot Analysis: A 1:30,000 diluiton of this antibody detected phospho-MKK4 (Ser257/Thr261) in 500 ng of activated MKK4 recombinant protein. Peptide inhibition was observed with the addition of phospho peptides, but not with the addition of non-phospho peptides or antibody alone (500 ng of recombinant protein was loaded onto the SDS-PAGE gel. It is recommended for end-users to determine optimal antibody dilutions respective to the amount of test sample used.).

Usage Statement

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 µL

Transport Information

Supplemental Information

Specifications

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Anti-phospho-MEK4 (Ser257/Thr261)

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