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ANTI-MEF2 200UL

市场价：: 0.00

促销价：: ¥0.00

货号：07-616

品牌：Millipore 密理博

配送至：

北京朝阳

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数量：

EA (预计3-5工作日到货)

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Replacement Information

重要规格表

Empirical Formula	CAS #
C₁₈H₂₆N₂O₂	566914-00-9

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
407616-10MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知 <a class="null" href="null">联系客户服务</a> Contact Customer Service <a class="null" href="null">联系客户服务</a> <a class="null" href="null">联系客户服务</a>	塑胶安瓿;塑胶针药瓶	10 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数以订单确认为准更多信息您节约了 ( )。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
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Description
Overview	A cell-permeable, end protected L-valyl derivative modeled on the MyD88-binding sequence of the TIR (Toll/IL-1R/resistance) domain BB-loop of IL-1RI (type I IL-1 receptor). It specifically inhibits TIR domain-mediated MyD88/IL1-RI interaction without affecting TLR4/MyD88 interaction. It was used successfully to reduce IL-1β-induced fever in mice in vivo and to attenuate IL-1β-induced, but not LPS-induced, activation of MAP kinase signaling cascades in murine lymphocytes and EL4 thymoma cells in vitro.
Catalogue Number	407616
Brand Family	Calbiochem®
Synonyms	BB-loop Mimic, Hydrocinnamoyl-L-valyl Pyrrolidine, TIR Domain Mimic

References
References	Bartfai, T., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 7971.

Product Information
CAS number	566914-00-9
ATP Competitive	N
Form	Colorless oil
Hill Formula	C₁₈H₂₆N₂O₂
Chemical formula	C₁₈H₂₆N₂O₂
Reversible	N
Structure formula Image

Applications
Application	IL-1R Antagonist, CAS 566914-00-9, is a cell-permeable, end protected L-valyl derivative. Specifically blocks TIR domain-mediated MyD88/IL1-RI interaction without affecting TLR4/MyD88 interaction.

Biological Information
Primary Target	TIR domain-mediated MyD88/IL1-RI interaction
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

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