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Parkin (c-Myc tagged), active 10ug

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货号：23-046

品牌：Millipore 密理博

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Replacement Information

重要规格表

Key Applications Species Cascade Component
Enzyme Assays Human E3
Description
Catalogue Number 23-046M
Brand Family Upstate
Trade Name
  • Upstate
Description Parkin (c-Myc tagged) Protein, active, 250 µg
Alternate Names
  • Parkinson juvenile disease protein 2
  • PARK2
  • PRKN
Background Information Parkin is an E3-ubiquitin ligase belonging to the RBR (RING – In Between RING – RING) family. Mutations in Parkin that result in a loss-of-function are the most frequent cause of familial Parkinson’s disease and are responsible for a large percentage of autosomal recessive juvenile parkinsonism (AR-JP). In addition to its auto-ubiquitination, Parkin can also ubiquitinate various substrates, including the CDK2-interacting protein cyclin E1, the α-synuclein-interacting protein synphilin-1, the synaptic vesicle-associated CDC-rel1 and the p38 subunit of aminoacyl-tRNA synthetase/JTV-1. Ubiquitination of substrates occurs in conjunction with the E2 enzymes UbcH7, UbcH8 or UbcH13/Uev1.
References
Product Information
Applications
Application Active, full length, recombinant human Parkin. N-terminal c-Myc, 6His-tagged. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.
Key Applications
  • Enzyme Assays
Biological Information
Cascade Component E3
Entrez Gene Number
Purification Method Purified using immobilized metal affinity chromatography.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Packaging Information
Material Size 250 µg
Transport Information
Supplemental Information
Specifications

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