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c-Jun (1-169)-GST, soluble 250ug

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号:14-195M

牌:Millipore 密理博

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Replacement Information
Description
Catalogue Number 14-195
Brand Family Upstate
Trade Name
  • Upstate
Description c-Jun (1-169)-GST Protein, soluble, 100 µg
Overview N-terminal, Glutathione-Stransferase (GST) tagged, fusion protein
References
Product Information
Applications
Application 100 µg of c-Jun (1-169)-GST. Soluble, N-terminal, Glutathione-Stransferase (GST) tagged, fusion protein, for use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
Source corresponding to truncated human c-Jun (1-169) expressed in E. coli
Specific Activity For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene Summary This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies.
Gene Symbol
  • JUN
  • AP1
  • p39
  • c-Jun
Protein Target c-Jun
Purification Method Glutathione agarose affinity chromatography
UniProt Number
UniProt Summary FUNCTION: SwissProt: P05412 # Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'.
SIZE: 331 amino acids; 35676 Da
SUBUNIT: Interacts with FOS to form a dimer. Interacts with SMAD3/SMAD4 heterodimers. Interacts with MYBBP1A, SPIB and TCF20. Interacts with COPS5; indirectly leading to its phosphorylation. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA.
SUBCELLULAR LOCATION: Nucleus.
PTM: Phosphorylation enhances the transcriptional activity. Phosphorylated by PRKDC.
SIMILARITY: SwissProt: P05412 ## Belongs to the bZIP family. Jun subfamily. & Contains 1 bZIP domain.
Molecular Weight 41 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by phosphorylation of GST
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 1 year at -20 C
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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