p70 S6 Kinase (1-421,D18H,T412E) 10ug - 炼石商城

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p70 S6 Kinase (1-421,D18H,T412E) 10ug

市场价：: 0.00

促销价：: ¥0.00

货号：14-333

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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Replacement Information

重要规格表

Empirical Formula	CAS #
C₂₈H₂₈N₄O₂ · HCl	145333-02-4

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Description
Overview	A selective cell-permeable protein kinase C inhibitor. Displays about 10-fold greater selectivity for PKC_α (IC₅₀ = 9 nM) and 4-fold greater selectivity for PKC_βI (IC₅₀ = 28 nM) over PKC_ε (IC₅₀ = 108 nM). Also prevents T cell-driven chronic inflammatory responses in vivo. Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number	557525
Brand Family	Calbiochem®
Synonyms	2-{8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl}-3-(1-methyl-1H-indol-3-yl)maleimide, HCl, Bisindolylmaleimide XI, HCl, 3-(8-((dimethylamino)methyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-y1)-4-(1-methyl-1H-indol-3-y1)-1H-pyrrole-2,5-dione hydrochloride

References
References	Birchall, A.M., et al. 1994. J. Pharmacol. Exp. Ther. 268, 922. Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.

Product Information
CAS number	145333-02-4
ATP Competitive	N
Form	Red solid
Hill Formula	C₂₈H₂₈N₄O₂ · HCl
Chemical formula	C₂₈H₂₈N₄O₂ · HCl
Reversible	N
Structure formula Image

Applications

Biological Information
Primary Target	PKCα
Primary Target IC<sub>50</sub>	9 nM, 28 nM, 108 nM, against PKCα, PKCβI, and PKCε, respectively
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

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