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Qiagen 凯杰 Biosharp Omega

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ZIPK, active 250ug

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货号：14-608M

品牌：Millipore 密理博

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Replacement Information
Description
Catalogue Number 14-608
Brand Family Upstate
Trade Name
  • Upstate
Description ZIPK Protein, active, 10 µg
Overview N-terminal, GST tagged, recombinant, of human ZIPK amino acids 1-290
References
Product Information
Applications
Application Active, N-terminal, GST tagged, recombinant, of human ZIPK amino acids 1-290, for use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
Source expressed in E. coli
Specific Activity For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene Summary Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis.
Gene Symbol
  • DAPK3
  • FLJ36473
  • ZIP-kinase
  • ZIPK
  • Dlk
  • ZIP
Protein Target ZIPK
Purification Method Glutathione agarose affinity chromatography
Target Sub-Family CAMK
UniProt Number
UniProt Summary FUNCTION: SwissProt: O43293 # Serine/threonine kinase which acts as a positive regulator of apoptosis. Phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis.
COFACTOR: Magnesium.
SIZE: 454 amino acids; 52536 Da
SUBUNIT: Homodimer or forms heterodimers with ATF4. Both interactions require an intact leucine zipper domain and oligomerization is required for full enzymatic activity. Also binds to DAXX and PAWR, possibly in a ternary complex which plays a role in caspase activation. Interacts with AATF and CDC5L.
SUBCELLULAR LOCATION: Nucleus. Cytoplasm (By similarity). Note=Relocates to the cytoplasm on binding PAWR where the complex appears to interact with actin filaments (By similarity). Associates to centromeres from prophase to anaphase.
SIMILARITY: SwissProt: O43293 ## Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily. & Contains 1 protein kinase domain.
Molecular Weight 64.3kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by phosphorylation of 250μM ZIPtide
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 6 months at -70°C
Packaging Information
Material Size 10 µg
Transport Information
Supplemental Information
Specifications

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