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Qiagen 凯杰 Biosharp Omega

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RIPK2, active 250ug

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货号：14-612M

品牌：Millipore 密理博

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Replacement Information
Description
Catalogue Number 14-612
Brand Family Upstate
Trade Name
  • Upstate
Description RIPK2 Protein, active, 10 µg
Overview human RIPK2, amino acids 1-299
References
Product Information
Applications
Application Active, human RIPK2, amino acids 1-299, for use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
Source N-terminal His6-tagged, recombinant, human RIPK2 expressed by baculovirus in Sf21 insect cells
Specific Activity For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene Summary This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli.
Gene Symbol
  • RIPK2
  • RIP2
  • GIG30
  • RICK
  • CARDIAK
  • CARD3
  • CCK
  • RIP-2
Protein Target RIPK2
Purification Method Ni2+/NTA-agarose
Target Sub-Family TKL
UniProt Number
UniProt Summary FUNCTION: SwissProt: O43353 # Activates pro-caspase-1 and pro-caspase-8. Potentiates CASP8-mediated apoptosis. Activates NF-kappa-B.
SIZE: 540 amino acids; 61195 Da
SUBUNIT: Binds to CFLAR/CLARP and CASP1 via their CARD domains. Binds to BIRC3/c-IAP1 and BIRC2/c-IAP2, TRAF1, TRAF2, TRAF5 and TRAF6. May be a component of both the TNFRSF1A and TNRFSF5/CD40 receptor complex.
SUBCELLULAR LOCATION: Cytoplasm (Probable).
TISSUE SPECIFICITY: Detected in heart, brain, placenta, lung, peripheral blood leukocytes, spleen, kidney, testis, prostate, pancreas and lymph node.
PTM: Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: SwissProt: O43353 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. & Contains 1 CARD domain. & Contains 1 protein kinase domain.
Molecular Weight 37.8kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by phosphorylation of MBP
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 6 months at -70°C
Packaging Information
Material Size 10 µg
Transport Information
Supplemental Information
Specifications

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