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PAK6, active 250ug

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货号：14-633M

品牌：Millipore 密理博

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Replacement Information
Description
Catalogue Number 14-633
Brand Family Upstate
Trade Name
  • Upstate
Description PAK6 Protein, active, 10 µg
Overview N-terminal His6-tagged, recombinant, human PAK6, amino acids 382-end
References
Product Information
Applications
Application Active, N-terminal His6-tagged, recombinant, human PAK6, amino acids 382-end, for use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
Source baculovirus in Sf21 cells
Specific Activity For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene Summary This gene encodes a protein that shares a high degree of sequence similarity with p21-activated kinase (PAK) family members. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. The protein encoded by this gene was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. The p21-activated protein kinase 6 gene was found to be highly expressed in testis and prostate tissues and the encoded protein was shown to cotranslocate into the nucleus with AR in response to androgen.
Gene Symbol
  • PAK6
  • PAK-5
  • PAK-6
  • PAK5
Protein Target PAK6
Purification Method Ni2+/NTA-agarose
Target Sub-Family STE
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q9NQU5 # The activated kinase acts on a variety of targets (By similarity).
SIZE: 681 amino acids; 74869 Da
SUBUNIT: Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1 (By similarity). Interacts with the androgen receptor.
PTM: Autophosphorylated when activated by CDC42/p21 (By similarity).
SIMILARITY: SwissProt: Q9NQU5 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. & Contains 1 CRIB domain. & Contains 1 protein kinase domain.
Molecular Weight 37.9kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by phosphorylation of PAKtide
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 6 months at -70°C
Packaging Information
Material Size 10 µg
Transport Information
Supplemental Information
Specifications

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