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EphA3, active 250ug

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货号：14-644M

品牌：Millipore 密理博

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Replacement Information
Description
Catalogue Number 14-644
Brand Family Upstate
Trade Name
  • Upstate
Description EphA3 Protein, active, 10 µg
Overview N-terminal 6His-tagged, recombinant, human EphA3 amino acids 578-end.
References
Product Information
Applications
Application Active, N-terminal 6His-tagged, recombinant, human EphA3 amino acids 578-end. For use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
Source Human EphA3 amino acids 578-end, expressed by baculovirus in Sf21 insect cells.
Specific Activity For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene Summary This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene.
Gene Symbol
  • EPHA3
  • HEK4
  • ETK1
  • HEK
  • TYRO4
  • ETK
  • EphA3
Protein Target EphA3
Purification Method Ni2+/NTA-agarose
Target Sub-Family TK
UniProt Number
UniProt Summary FUNCTION: SwissProt: P29320 # Receptor for members of the ephrin-A family. Binds to ephrin-A2, -A3, -A4 and -A5. Could play a role in lymphoid function.
SIZE: 983 amino acids; 110131 Da
SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.
TISSUE SPECIFICITY: Widely expressed. Highest level in placenta.
DISEASE:SwissProt: P29320 # Defects in EPHA3 may be a cause of colorectal cancer (CRC) [MIM:114500].
SIMILARITY: SwissProt: P29320 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. & Contains 2 fibronectin type-III domains. & Contains 1 protein kinase domain. & Contains 1 SAM (sterile alpha motif) domain.
Molecular Weight 49kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by phosphorylation of Poly (Glu4-Tyr) (4:1)
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 6 months at -70°C
Packaging Information
Material Size 10 µg
Transport Information
Supplemental Information
Specifications

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