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DYRK2, active 250ug

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货号：14-669M

品牌：Millipore 密理博

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Replacement Information
Description
Catalogue Number 14-669
Brand Family Upstate
Trade Name
  • Upstate
Description DYRK2 Protein, active, 10 µg
Overview 6His-tagged, recombinant, full length human DYRK2
References
Product Information
Applications
Application Active, 6His-tagged, recombinant, full length human DYRK2, for use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
Source expressed by baculovirus in Sf21 cells
Specific Activity For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene Summary DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert.
Gene Symbol
  • DYRK2
  • FLJ21365
  • FLJ21217
Protein Target DYRK2
Purification Method Ni2+/NTA-agarose
Target Sub-Family CMGC
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q92630 # Role in the regulation of cellular growth and/or development. Regulates TP53 by phosphorylation on Ser-46 to induce apoptosis in response to DNA damage, functioning downstream of ATM. Inactivates GYS1 by phosphorylation at Ser-641, and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3, and may play a more general role in the priming of GSK3 substrates.
COFACTOR: Magnesium. & Manganese.
SIZE: 601 amino acids; 66652 Da
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocates into the nucleus following DNA damage.
TISSUE SPECIFICITY: Testis, after the onset of spermatogenesis.
PTM: Phosphorylated on serine/threonine residues (By similarity).
SIMILARITY: SwissProt: Q92630 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. & Contains 1 protein kinase domain.
Molecular Weight 63.5kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by phosphorylation of casein
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 6 months at -70°C
Packaging Information
Material Size 10 µg
Transport Information
Supplemental Information
Specifications

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