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EphA8, active 250ug

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货号：14-673M

品牌：Millipore 密理博

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Replacement Information
Description
Catalogue Number 14-673
Brand Family Upstate
Trade Name
  • Upstate
Description EphA8 Protein, active, 10 µg
Overview N-terminal 6His-tagged, recombinant, human EphA8 residues 615-911
References
Product Information
Applications
Application Active, N-terminal 6His-tagged, recombinant, human EphA8 residues 615-911, for use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
Source expressed by baculovirus in Sf21 cells
Specific Activity For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene Summary This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system.
Gene Symbol
  • EPHA8
  • HEK3
  • KIAA1459
  • EphA8
  • EEK
  • Hek3
Protein Target EphA8
Purification Method Ni2+/NTA-agarose
Target Sub-Family TK
UniProt Number
UniProt Summary FUNCTION: SwissProt: P29322 # Receptor for members of the ephrin-A family.
SIZE: 1005 amino acids; 111003 Da
SUBUNIT: Interacts with FYN (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
PTM: Phosphorylation on Tyr-616 is critical for association with FYN (By similarity). & Phosphorylation on Tyr-839 modulates tyrosine kinase activity (By similarity).
SIMILARITY: SwissProt: P29322 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. & Contains 2 fibronectin type-III domains. & Contains 1 protein kinase domain. & Contains 1 SAM (sterile alpha motif) domain.
Molecular Weight 37.1 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by phosphorylation of PDKtide (Catalog # 12-401)
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 6 months at -70°C from date of shipment
Packaging Information
Material Size 10 µg
Transport Information
Supplemental Information
Specifications

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