Anti SREBP-2, clone 2545

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Anti SREBP-2, clone 2545

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货号：04-479

品牌：Millipore 密理博

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	ELISA, WB	M	Ascites	Monoclonal Antibody

Description
Catalogue Number	04-479
Brand Family	Upstate
Trade Name	Upstate
Description	Anti-SREBP-2 Antibody, clone 2545
Alternate Names	SREBP2 sterol regulatory element binding transcription factor 2

References

Product Information
Format	Ascites
Presentation	200 μL of mouse ascites of monoclonal IgG1 with 0.1% sodium azide.

Applications
Application	Use Anti-SREBP-2 Antibody, clone 2545 (Mouse Monoclonal Antibody) validated in ELISA, WB to detect SREBP-2 also known as sterol regulatory element binding transcription factor 2.
Key Applications	ELISA Western Blotting

Biological Information
Immunogen	Recombinant GST-tagged human SREBP-2 protein encompassing amino acids 48-403.
Clone	Clone 2545
Host	Mouse
Specificity	Reacts with both the precursor and mature forms of SREBP-2,
Isotype	IgG1
Species Reactivity	Human
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NM_004599.2
Entrez Gene Summary	This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain.
Gene Symbol	SREBF2 OTTHUMP00000028740 SREBP-2 SREBP2
UniProt Number	Q12772
UniProt Summary	FUNCTION: SwissProt: Q12772 # Transcriptional activator that binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes. SIZE: 1141 amino acids; 123688 Da SUBUNIT: Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols. TISSUE SPECIFICITY: Ubiquitously expressed in adult and fetal tissues. PTM: Under sterol-depleted conditions, SREBPs are cleaved sequentially by site-1 and site-2 protease. The first cleavage occurs within the luminal loop and is directly regulated by sterols. The second cleavage by site-2 protease occurs within the first transmembrane stretch and liberates the soluble transcription factor. Cleavage by the cysteine proteases, caspase- 3 and caspase-7, is induced during apoptosis, independent of sterol levels. SIMILARITY: SwissProt: Q12772 ## Contains 1 basic helix-loop-helix (bHLH) domain. MISCELLANEOUS: SREBPs have to be in a complex with the cleavage- activating protein (SCAP) to move to the Golgi and be cleaved by site-1 protease.
Molecular Weight	124 kDa

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Routinely evaluated by immunoblot.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/ thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.

Storage and Shipping Information

Storage Conditions

Stable for 2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/ thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.