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Anti-phospho-HP1 gamma (Ser83)

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货号：07-972

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB Rb Purified Polyclonal Antibody
Description
Catalogue Number 07-972
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-phospho-HP1 γ (Ser83) Antibody
Alternate Names
  • Chromobox protein homolog 3
  • Heterochromatin protein 1 homolog gamma
  • Modifier 2 protein
  • HECH
References
Product Information
Format Purified
Presentation Immunoaffinity purified rabbit IgG in PBS containing 30% glycerol.
Applications
Application Anti-phospho-HP1 γ (Ser83) Antibody is a Rabbit Polyclonal Antibody for detection of phospho-HP1 γ (Ser83) also known as Heterochromatin protein 1 homolog gamma, HECH & has been validated in WB.
Key Applications
  • Western Blotting
Biological Information
Immunogen Phosphopeptide corresponding to amino acid position 76-88 (DGTKRKpSLSDSE-88) of human HP1 gamma.
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity HP1γ phosphorylated at Ser83.
Isotype IgG
Species Reactivity
  • Human
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.
Gene Symbol
  • CBX3
  • HP1-GAMMA
  • HP1Hs-gamma
  • HECH
Modifications
  • Phosphorylation
Purification Method ImmunoAffinity Purified
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q13185 # Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
SIZE: 183 amino acids; 20811 Da
SUBUNIT: Binds directly to CHAF1A. Interacts with histone H3 methylated at 'Lys-9'. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Interacts with LBR, INCENP, TRIM28/TIF1B, SUV420H1, SUV420H2 and SP100. Interacts with TIF1A (By similarity). Interacts with MIS12 and C20orf127. Can interact directly with CBX5 via the chromoshadow domain.
SUBCELLULAR LOCATION: Nucleus (Potential). Note=Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis (Potential).
PTM: Phosphorylated by PIM1. Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.
SIMILARITY: SwissProt: Q13185 ## Contains 2 chromo domains.
Molecular Weight 20 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Routinely evaluated by immunoblot.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 2 years at -20°C from date of shipment.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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