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Anti-Cytohesin-1, clone 7H2 (rat monoclonal)

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货号：MABT14

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB, IF, IP R Purified Monoclonal Antibody
Description
Catalogue Number MABT14
Description Anti-Cytohesin-1 Antibody, clone 7H2
Alternate Names
  • cytohesin 1
  • cytoadhesin 1
  • CYTOHESIN-1
  • pleckstrin homology, Sec7 and coiled-coil domains 1
  • homolog of secretory protein SEC7
  • PH, SEC7 and coiled-coil domain-containing protein 1
  • SEC7 homolog B2-1
Background Information Cytohesin-1 is a guanine nucleotide exchange factor and an integrin binding protein belonging to a closely related group of proteins known as the cytohesion family. Cytohesin-1 contains 2 domains; a C-terminal, pleckstrin homology (PH) domain, and a central, large Sec7 domain. The PH domain serves to mediate the proteins functional regulation and the reversible membrane recruitment. The Sec7 domain acts as the primary regulator for phosphoinositide-dependent membrane attachment of the protein. Cytohesin-1 appears to have an integral role in integrin alphaLbeta2 adhesive function, and in the activation of integrin mediated pathways involved in wound healing, and immune system cell-cell/ cell-matrix interactions. It is highly expressed in natural killer and peripheral T cells. There are two known isoforms produced by alternative splicing.
References
Product Information
Format Purified
Control
  • Jurkat cell lysate
Presentation Purified rat monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application This Anti-Cytohesin-1 Antibody, clone 7H2 is validated for use in WB, IF, IP for the detection of Cytohesin-1.
Key Applications
  • Western Blotting
  • Immunofluorescence
  • Immunoprecipitation
Application Notes Immunoprecipitation Analysis: A previous lot was used by an independent laboratory in IP. (Boehm, 2003).

Immunofluorescence Analysis: A previous lot was used by an independent laboratory in IP. (Boehm, 2003).
Biological Information
Immunogen Histidine-tagged recombinant protein corresponding to human Cytohesin-1.
Epitope Unknown
Clone 7H2
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rat
Specificity The antibody recognizes Cytohesin-1.
Isotype IgG1κ
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. The encoded protein is 83% homologous to that of CYTH2. [provided by RefSeq].
Gene Symbol
  • B2-1
  • PSCD1
  • CYTH1
  • SEC7
Purification Method Protein G Purified
UniProt Number
UniProt Summary FUNCTION: Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF through replacement of GDP with GTP.

SUBUNIT STRUCTURE: Interacts with TRIM23 and CYTIP.

TISSUE SPECIFICITY: Ubiquitous.

SEQUENCE SIMILARITIES: Contains 1 PH domain.

Contains 1 SEC7 domain.
Molecular Weight ~ 46 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western blot in Jurkat cell lysate.

Western blot Analysis: 0.5 µg/mL of this antibody detected Cytohesin-1 in 10 µg of Jurkat cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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