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Anti-Podocalyxin-like protein I, clone mAb 85 (mouse monoclonal)

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货号：MAB4433

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H ICC, FC, WB M Purified Monoclonal Antibody
Description
Catalogue Number MAB4433
Description Anti-Podocalyxin-like protein I Antibody, clone 85
Alternate Names
  • podocalyxin-like
Background Information Podocalyxin-like protein 1(Podocalyxin) is a transmembrane protein known to be heavily sialyated and sulfated that is localized on the apical surface of podocytes and on vascular endothelia. Originally, the protein was characterized as a marker for vasculature and podocytes, but expression has since been observed in platelets, hematopoietic precursor cells and mesothelial cells from the coelmic cavity lining. Studies have outlined two distinct and seemingly adverse roles for this protein; it acts as an anti-adhesion molecule in renal glomerulae podocytes, but functions as an adhesion molecule within vasculature on high endothelial venules. Podocalyxin expression has been implicated in the development of aggressive cancers, beta catenin signaling, angiogenisis, and both myeloid and acute lymphoblastic leukemias.
References
Product Information
Format Purified
Control
  • Human embryonic stem cells
Presentation Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
Applications
Application Detect Podocalyxin-like protein I using this Anti-Podocalyxin-like protein I Antibody, clone 85 validated for use in IC, FC & WB.
Key Applications
  • Immunocytochemistry
  • Flow Cytometry
  • Western Blotting
Application Notes Western Blot Analysis: A previous lot was used by an independent laboratory in WB (Choo, A., et al., 2008).

Flow Cytometry Analysis: A previous lot was used by an independent laboratory in FC (Choo, A., et al., 2008).
Biological Information
Immunogen Human embryonic stem cells.
Epitope Extracellular Domain
Clone clone 85
Host Mouse
Specificity This antibody recognizes the extracellular domain of Podocalyxin-like protein 1.
Unlike it's counterpart (clone mAb 84, MAB4414), this antibody is not cytotoxic.
Isotype IgMκ
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin. [provided by RefSeq].
Gene Symbol
  • PCLP
  • Gp200
  • PC
  • PCLP1
Purification Method Ion exchange purification column
UniProt Number
UniProt Summary FUNCTION: Functions as an antiadhesin that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion.

SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein Potential.

TISSUE SPECIFICITY: Glomerular epithelium cell (podocyte).

PTM: Glycosylated; contains sialic acid.

SEQUENCE SIMILARITIES: Belongs to the podocalyxin family.
Molecular Weight ~55 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Immunocytochemistry in human embryonic stem cells.

Immunocytochemistry Analysis: A 1:50 dilution of this antibody detected Podocalyxin-like protein I in human embryonic stem cells.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 200 µL
Transport Information
Supplemental Information
Specifications

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