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Anti-Neuropilin-1 (rabbit polyclonal)

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货号：AB10521

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
R, M WB, IHC, IP, IF Rb Serum Polyclonal Antibody
Description
Catalogue Number AB10521
Description Anti-Neuropilin-1 Antibody
Alternate Names
  • CD304 antigen
  • Vascular endothelial cell growth factor 165 receptor
  • neuropilin 1
  • transmembrane receptor
  • Npn 1
Background Information Neuropilin-1 is a type 1 membrane protein with three distinct functions. First, it can mediate cell adhesion via a heterophilic molecular interaction. Second, in neuronal cells, neuropilin-1 binds the class 3 semaphorins, which are neuronal chemorepellents, and plays a role in the directional guidance of axons. It is expected to form complexes with the plexinA subfamily members and mediate the semaphorin-elicited inhibitory signals into neurons. Third, in endothelial cells, neuropilin-1 binds a potent endothelial cell mitogen, vascular endothelial growth factor (VEGF)165, and regulates vessel formation.
References
Product Information
Format Serum
Control
  • PC12 cell lysate
Presentation Rabbit serum in buffer containing 0.05% sodium azide.
Applications
Application This Anti-Neuropilin-1 Antibody is validated for use in WB, IH, IP, IF for the detection of Neuropilin-1.
Key Applications
  • Western Blotting
  • Immunohistochemistry
  • Immunoprecipitation
  • Immunofluorescence
Biological Information
Immunogen This antibody is generated from rabbits immunized with a His-tagged partial recombinant rat Neuropilin-1.
Epitope Unknown
Host Rabbit
Specificity This antibody recognizes Neuropilin-1.
Isotype IgG
Species Reactivity
  • Rat
  • Mouse
Species Reactivity Note Proven to react with mouse and rat. Human-94% homology
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary NRP1 is a membrane-bound coreceptor to a tyrosine kinase receptor for both vascular endothelial growth factor (VEGF; MIM 192240) and semaphorin (see SEMA3A; MIM 603961) family members. NRP1 plays versatile roles in angiogenesis, axon guidance, cell survival, migration, and invasion.[supplied by OMIM]
Gene Symbol
  • NRP1
  • NRP
  • NP1
  • BDCA4
  • CD304
  • neuropilin-1
Purification Method Unpurified
UniProt Number
UniProt Summary FUNCTION: Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis (By similarity).
SUBUNIT: Heterodimer with NRP2 (Probable). Binds PLXNB1 (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Found in the embryonic nervous system.
SIMILARITY: Belongs to the neuropilin family.
Contains 2 CUB domains.
Contains 2 F5/8 type domains.
Contains 1 MAM domain.
Molecular Weight 130 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in PC12 cell lysate.
Western Blot Analysis: : 1:1,000 dilution of this antibody detected Neuropilin 1 on 10 µg of PC12 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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