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Anti-TKS5 (SH3 #1) (rabbit polyclonal)

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货号：09-403

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M WB, ICC, IP Rb Purified Polyclonal Antibody
Description
Catalogue Number 09-403
Description Anti-TKS5 (SH3 #1) Antibody
Alternate Names
  • Adaptor protein TKS5
  • Five SH3 domain-containing protein
  • SH3 and PX domains 2A
  • SH3 multiple domains 1
  • SH3 multiple domains protein 1
  • five SH3 domains
Background Information Tks5 (previously known as Fish), is a large scaffolding protein with one amino-terminal PX domain and five SH3 domains. It is cytoplasmic in normal fibroblasts. In Src-transformed cells, Tks5 localizes to podosomes. The coexpression of Tks5 and constitutively active Src in epithelial cancer cells resulted in the appearance of podosomes/invadopodia. Cells with reduced Tks5 expression are poorly invasive through matrigel. Tks5 is expressed and localized to podosomes/invadopodia in some invasive human cancer cell lines and tumor tissue, particularly breast cancers and melanomas. Thus, Tks5 appears to be required for podosome/invadopodia formation and for invasion of some cancer cells.
References
Product Information
Format Purified
Control
  • Western Blot::
    NIH-3T3 (100% confluent) lysate
    Immunocytochemistry:
    Mouse 3T3-Src(Y527F) cells
Presentation Purified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3.
Applications
Application Anti-TKS5 (SH3 #1) Antibody detects level of TKS5 (SH3 #1) & has been published & validated for use in WB, IC & IP.
Key Applications
  • Western Blotting
  • Immunocytochemistry
  • Immunoprecipitation
Application Notes Western Blot Analysis: Antibody detected TKS5 in 20 μg of NIH-3T3 (100% confluent) lysate.
Biological Information
Immunogen Recombinant Protein, aa: 166-225. Homology: Human, Dog, Horse, Rat, Cow (100%, 60/60); Chicken (93%, 56/60)
Epitope 166-225 aa
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Species Reactivity
  • Human
  • Mouse
Species Reactivity Note Reacts with Mouse and Human. Other homologies: Human, Canine, Equine, Rat, and Bovine (100% sequence homology), Chicken (93% sequence homology)
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • FISH
  • KIAA0418
  • SH3MD1
  • Sh3pxd2a
  • MGC144076
Purification Method Protein A Purfied
UniProt Number
UniProt Summary Function: Required for podosome formation, degradation of the extracellular matrix, and for the invasiveness of some cancer cells. Binds phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,4-biphosphate (PtdIns(3,4)P2). In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide By similarity.

Subunit: structure Interacts with ADAM12, ADAM15 and ADAM19 By similarity.

Subcellular location: Cytoplasm. Cell projection › podosomeBy similarity. Note= Cytoplasmic in normal cells and localizes to podosomes in Src-transformed cells By similarity.

Tissue specificity: Widely expressed. Not found in the spleen and testis. Ref.1

Domain: The PX domain is required for podosome localization, and for binding phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,4-biphosphate (PtdIns(3,4)P2) By similarity.

The fifth SH3 domain mediates binding with ADAM12, ADAM15 and ADAM19 By similarity.

Post-translational modification: Tyrosine phosphorylated by SRC. Phosphorylation plays a regulatory role in the protein localization. The intramolecular interaction of the PX domain with the third SH3 domain maintains the protein in the cytoplasm and phosphorylation disrupts this interaction, resulting in the redistribution of the protein from cytoplasm to the perimembrane region. Phosphorylated on serine upon DNA damage, probably by ATM or ATR By similarity.

Sequence similarities: Belongs to the SH3PXD2 family.
Contains 1 PX (phox homology) domain.
Contains 5 SH3 domains.
Molecular Weight 130-150 kDa. Uncharacterized bands(s) may be observed in some cell lysates.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Routinely evaluated by Western Blot on NIH-3T3 (100% confluent) lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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