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Anti-Na + K + Cl - Cotransporter 2 (rabbit polyclonal)

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货号：AB2281

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
R, M, H WB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number AB2281
Description Anti-Na+K+Cl- Cotransporter 2 Antibody
Alternate Names
  • Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2
  • Kidney-specific Na-K-Cl symporter
  • NKCC2A variant A
  • Na-K-2Cl cotransporter
  • sodium potassium chloride cotransporter 2
  • solute carrier family 12 (sodium/potassium/chloride transporters), member 1
Background Information The sodium-potassium-chloride cotransporter isoform 2 is kidney-specific and is found on the apical membrane of the thick ascending limb of Henle's loop and the macula densa. It accounts for most of the NaCl resorption with the stoichiometry of 1Na:1K:2Cl and is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. SLC12A1 is kidney specific and is essential in the regulation of ionic balance and cell volume. It is a component of an electrically silent transporter system, mediating sodium and chloride reabsorption. Defects in SLC12A1 are the cause of Bartter syndrome type 1, an autosomal recessive disorder characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria.
References
Product Information
Format Affinity Purified
Control
  • Rat liver lysates
Presentation Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3.
Applications
Application Anti-Na+K+Cl-Cotransporter 2 Antibody detects level of Na+K+Cl-Cotransporter 2 & has been published & validated for use in WB.
Key Applications
  • Western Blotting
Biological Information
Immunogen KLH conjugate followed by NA+K+CL- Cotransporter 2 corresponding to the cytoplasmic domain.
Epitope Cytoplasmic domain
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity This antibody recognizes the cytoplasmic domain of NA+K+CL- Cotransporter 2.
Species Reactivity
  • Rat
  • Mouse
  • Human
Species Reactivity Note Proven to react with human, rat and mouse.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary The sodium-potassium-chloride cotransporter isoform 2 is kidney-specific and is found on the apical membrane of the thick ascending limb of Henle's loop and the macula densa. It accounts for most of the NaCl resorption with the stoichiometry of 1Na:1K:2Cl and is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. [provided by RefSeq].
Gene Symbol
  • SLC12A1
  • BSC1
  • MGC48843
  • NKCC2
Purification Method Antigen Affinity Purified
UniProt Number
UniProt Summary FUNCTION: Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.

SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.

TISSUE SPECIFICITY:Kidney specific.

DISEASE: Defects in SLC12A1 are the cause of Bartter syndrome type 1 (BS1) [MIM:601678]. BS refers to a group of autosomal recessive disorders characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. BS1 is a life-threatening condition beginning in utero, with marked fetal polyuria that leads to polyhydramnios and premature delivery. Another hallmark of BS1 is a marked hypercalciuria and, as a secondary consequence, the development of nephrocalcinosis and osteopenia. Ref.1

SIMILARITIY: Belongs to the SLC12A transporter family.
Molecular Weight ~150 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Western Blot Analysis:
1:2,000 dilution of this lot detected NA+K+CL- Cotransporter 2 on 10 µg of rat liver lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8ºC from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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