Anti-phospho-Smad3 (Ser423/425) (rabbit polyclonal) - 炼石商城

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Anti-phospho-Smad3 (Ser423/425) (rabbit polyclonal)

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货号：07-1389

品牌：Millipore 密理博

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重要规格表

Species Reactivity	Key Applications	Host	Antibody Type
M, Mi, H, R	WB	Rb	Polyclonal Antibody

Description
Catalogue Number	07-1389
Description	Anti-phospho-Smad3 (Ser423/425) Antibody
Alternate Names	MAD, mothers against decapentaplegic homolog 3 MAD, mothers against decapentaplegic homolog 3 (Drosophila) Mothers against DPP homolog 3 SMA- and MAD-related protein 3 SMAD 3 SMAD family member 3 SMAD, mothers against DPP homolog 3 SMAD, mothers against DPP homolog 3 (Drosophila) mad homolog JV15-2 mad protein homolog mothers against decapentaplegic homolog 3
Background Information	Members of the Smad family of signal transduction molecules are components of a critical intracellular pathway that transmits TGF-β signals from the cell surface into the nucleus. Three distinct classes of Smads have been defined: the receptor-regulated Smads (R-Smads), which include Smad1, 2, 3, 5 and 8, the common-mediator Smad (co-Smad), Smad4, and the antagonistic or inhibitory Smads (I-Smads), Smad6 and 7. Once in the nucleus, Smads can target a variety of DNA binding proteins to regulate transcriptional responses. Following stimulation by TGF-β, Smad2 and Smad3 become phosphorylated at their carboxyl termini (Ser465 and 467 on Smad2; Ser423 and 425 on Smad3) by TGF-β Receptor I. Phosphorylated Smad 2/3 can complex with Smad4, translocate to the nucleus and regulate gene expression.

References

Product Information
Presentation	Unpurified rabbit serum in buffer containing 0.05% sodium azide.

Applications
Application	Anti-phospho-Smad3 (Ser423/425) Antibody is a Rabbit Polyclonal Antibody for detection of phospho-Smad3 (Ser423/425) also known as MAD Mothers against DPP homolog 3 & has been validated in WB.
Key Applications	Western Blotting

Biological Information
Immunogen	KLH-conjugated, synthetic phospho-peptide corresponding to residues surrounding Ser423/425 of human Smad3.
Epitope	Phosphorylated Ser423/425
Host	Rabbit
Specificity	Detects phosphorylated Smad3 (Ser423 and Ser425).
Species Reactivity	Mouse Mink Human Rat
Species Reactivity Note	Mouse and Mink. Predicted to react with Human and Rat based on sequence homology.
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NM_005902
Gene Symbol	DKFZp586N0721 DKFZp686J10186 HSPC193 HsT17436 JV15-2 MADH3 MGC60396 Mad3 hMAD-3 hSMAD3
Modifications	Phosphorylation
UniProt Number	P84022
UniProt Summary	FUNCTION: Transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinase. SMAD3 is a receptor-regulated SMAD (R-SMAD) By similarity. SUBUNIT STRUCTURE: Interacts with HGS. Interacts with NEDD4L in response to TGF-beta. Interacts with TTRAP By similarity. Interacts with SARA (SMAD anchor for receptor activation); form trimers with another SMAD3 and the co-SMAD SMAD4. Interacts with JUN/FOS, vitamin D receptor, homeobox protein TGIF and TGIF2, PEBP2-alpha C subunit, CREB-binding protein (CBP), p300, SKI, SNON, ATF2, SMURF2, AIP1, DACH1 and TGFB1I1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3. Found in a complex with SMAD2 and TRIM33 upon addition of TGF-beta. Interacts with SMAD2 and TRIM33. Found in a complex with SMAD3, Ran and XPO4. Interacts with XPO4. Interacts with LBXCOR1 and CORL2. SUBCELLULAR LOCATION: CytoplasmBy similarity. NucleusBy similarity. Note= In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with SMAD4 By similarity. DOMAIN: The MH2 domain is sufficient to carry protein nuclear export. PTM: Phosphorylated on serine by TGF-beta and activin type 1 receptor kinases. INVOLVEMENT IN DISEASE: Defects in SMAD3 may be a cause of colorectal cancer (CRC) [MIM:114500]. SEQUENCE SIMILARITIES: Belongs to the dwarfin/SMAD family. Contains 1 MH1 (MAD homology 1) domain. Contains 1 MH2 (MAD homology 2) domain.
Molecular Weight	50 kDa

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Materials Information

Toxicological Information

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Safety Information

Product Usage Statements
Quality Assurance	Evaluated by western blot on untreated and UV-treated AKR-2B cell lysate. Western Blot Analysis: 1:1,000 dilution of this antibody was used to detect Smad3 in UV-treated AKR-2B cell lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 2 years at -20°C from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution.

Packaging Information
Material Size	100 µL

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