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Anti-PADI4, C-terminus (rabbit polyclonal)

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货号：09-796

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB, ELISA Rb Purified Polyclonal Antibody
Description
Catalogue Number 09-796
Description Anti-PADI4 Antibody, CT
Alternate Names
  • HL-60 PAD
  • PADI-H protein
  • Peptidylarginine deiminase IV
  • Protein-arginine deiminase type IV
  • peptidyl arginine deiminase, type IV
  • peptidyl arginine deiminase, type V
  • protein-arginine deiminase
  • Protein-arginine deiminase type-4
Background Information PADI4 (Protein-arginine deiminase type-4) is a member of a family of enzymes responsible for the conversion of arginine residues to citrulline residues via catalysis of the deimination of the arginine residues. PADI4 down-regulates histone H3 and H4 arginine methylation, both by preventing arginine methylation by CARM1 and HRMT1L2/PRMT1 and by converting methylarginine to citrulline. This protein may play a role in granulocyte and macrophage development leading to inflammation and immune response.
References
Product Information
Format Purified
Control
  • HEK293 cell lysate
Presentation Purified rabbit polyclonal in buffer containing PBS and 0.09% sodium azide.
Applications
Application Anti-PADI4 Antibody, C-terminus is an antibody against PADI4 for use in WB, ELISA.
Key Applications
  • Western Blotting
  • ELISA
Application Notes ELISA: A 1:1000 dilution of a previous lot was used on ELISA.
Biological Information
Immunogen KLH-conjugated synthetic linear peptide corresponding to the C-terminal region of PADI4.
Epitope C-terminus
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity The antibody recognizes PADI4 at and around the C-terminus.
Species Reactivity
  • Human
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response.
[provided by RefSeq].
Gene Symbol
  • PADI4
  • PAD
  • PAD4
  • PADI5
  • PDI4
  • PDI5
Purification Method Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
UniProt Number
UniProt Summary FUNCTION: Catalyzes the citrullination/deimination of arginine residues of proteins. Citrullinates histone H3 at 'Arg-8' and/or 'Arg-17' and histone H4 at 'Arg-3', which prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1.

CATALYTIC ACTIVITY: Protein L-arginine + H2O = protein L-citrulline + NH3.

COFACTOR: Binds 5 calcium ions per subunit.

SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasmic granule. Note= Cytoplasmic granules of eosinophils and neutrophils.

TISSUE SPECIFICITY: Expressed in eosinophils and neutrophils, not expressed in peripheral monocytes or lymphocytes.

INVOLVEMENT IN DISEASE: PADI4 is thought to be a rheumatoid arthritis susceptibility locus [MIM:180300]. Could have an important role in the pathogenesis of rheumatoid arthritis by increasing citrullination of proteins in rheumatoid arthritis synovial tissues, leading, in a cytokine-rich milieu, to a break in tolerance to citrullinated peptides processed and presented in the appropriate HLA context.

SEQUENCE SIMILARITIES: Belongs to the protein arginine deiminase family.

BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters:

KM=0.055 mM for fibrinogen

KM=0.064 mM for filaggrin

Vmax=33.2 µmol/h/mg enzyme toward fibrinogen

Vmax=8.0 µmol/h/mg enzyme toward filaggrin

pH dependence:

Optimum pH is 6.5-9.0.
Molecular Weight ~74 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by western blot on HEK293 cell lysate.

Western Blotting Analysis: 1:25-1:500 dilution of this antibody detected PADI4 in HEK293 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 6 months at 2-8ºC from date of receipt. For long term storage, store at -20ºC
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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