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Anti-IGF2 mRNA-binding protein 3 (rabbit polyclonal)

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货号：07-104

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, Chp, Ca, Eq WB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number 07-104
Description Anti-IGF2 mRNA-binding protein 3 Antibody
Alternate Names
  • IGF II mRNA binding protein 3
  • IGF-II mRNA-binding protein 3
  • IGF2 mRNA-binding protein 3
  • KH domain containing protein overexpressed in cancer
  • KH domain-containing protein overexpressed in cancer
  • VICKZ family member 3
  • insulin-like growth factor 2 mRNA binding protein 3
Background Information The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor 2 leader 3 mRNA and may repress translation of insulin-like growth factor 2 during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq].
References
Product Information
Format Affinity Purified
Control
  • Hek293 cell lysate
Presentation Purified rabbit serum in PBS with 0.09% azide.
Applications
Application This Anti-IGF2 mRNA-binding protein 3 Antibody is validated for use in WB for the detection of IGF2 mRNA-binding protein 3.
Key Applications
  • Western Blotting
Application Notes Western Blot (SNAP ID) Analysis: 2 µg/mL from a previous lot detected IGF2 mRNA-binding protein 3 on 10 µg of Hek293 cell lysate.

Immunoprecipitation Analysis: A previous lot was used by an independent laboratory in IP.
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to human IGF2 mRNA-binding protein 3 at and around the C-terminus.
Epitope C-terminus
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity This antibody recognizes IGF2 mRNA-binding protein 3 at the C-terminus.
Species Reactivity
  • Human
  • Mouse
  • Chimpanzee
  • Canine
  • Horse
Species Reactivity Note Reacts with human and mouse. Predicted to react with chimpanzee, Rhesus monkey, dog, and horse based on 100% sequence homology.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor 2 leader 3 mRNA and may repress translation of insulin-like growth factor 2 during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq].
Gene Symbol
  • IMP-3
  • IMP3
  • KOC1
  • VICKZ3
  • hKOC
  • IGF2BP3
Purification Method Affinity Purfied
UniProt Number
UniProt Summary FUNCTION: RNA-binding protein that act as a regulator of mRNA translation and stability. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binds to sequences in the 3'-UTR of CD44 mRNA.

SUBUNIT STRUCTURE: Homodimer and multimer.

SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note: Found in lamellipodia of the leading edge, in the perinuclear region, and beneath the plasma membrane. The subcytoplasmic localization is cell specific and regulated by cell contact and growth. Localized at the connecting piece and the tail of the spermatozoa. Colocalized with CD44 mRNA in RNP granules.

TISSUE SPECIFICITY: Expressed in fetal liver, fetal lung, fetal kidney, fetal thymus, fetal placenta, fetal follicles of ovary and gonocytes of testis, growing oocytes, spermatogonia and semen (at protein level). Expressed in cervix adenocarcinoma, in testicular, pancreatic and renal-cell carcinomas (at protein level). Expressed ubiquitously during fetal development at 8 and 14 weeks of gestation. Expressed in ovary, testis, brain, placenta, pancreatic cancer tissues and pancreatic cancer cell lines.

INVOLVEMENT IN DISEASE: Autoantibodies against IGF2BP3 are detected in sera from some patients with a variety of carcinomas.

SEQUENCE SIMILARITIES: Belongs to the RRM IMP/VICKZ family.

Contains 4 KH domains.

Contains 2 RRM (RNA recognition motif) domains.
Molecular Weight 64 kDa was observed. Predicted to cross-react with all the Isoforms of IGF2BP3.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in Hek293 cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected IGF2 mRNA-binding protein 3 on 10 µg of Hek293 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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