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Anti-Insulin, clone MAB1 (mouse monoclonal)

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货号：05-1108

品牌：Millipore 密理博

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Replacement Information

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H IH(P) M Affinity Purified Monoclonal Antibody
Description
Catalogue Number 05-1108
Replaces CBL71
Description Anti-Insulin Antibody, clone1
Background Information Insulin is a polypeptide hormone that regulates carbohydrate metabolism. Apart from being the primary agent in carbohydrate homeostasis, it has effects on fat metabolism.
References
Product Information
Format Affinity Purified
Control
  • Human pancreas tissue.
Presentation The monoclonal is presented as 1mg in 1ml phosphate buffered saline containing 10mM sodium azide. We recommend that each laboratory determine an optimum working titre for use in its particular application.
Applications
Application Anti-Insulin Antibody, clone1 is an antibody against Insulin for use in IH(P).
Key Applications
  • Immunohistochemistry (Paraffin)
Biological Information
Immunogen Biosynthetic human insulin
Clone MAB1
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity This antibody recognizes an epitope including the amino acid B30.
Isotype IgG1
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Gene Symbol
  • ILPR
  • IRDN
  • OTTHUMP00000011161
  • OTTHUMP00000011162
  • OTTHUMP00000196038
  • insulin
  • proinsulin
Purification Method Affinity Purfied
UniProt Number
UniProt Summary FUNCTION: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
SUBUNIT STRUCTURE: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
SUBCELLULAR LOCATION: Secreted.
INVOLVEMENT IN DISEASE: Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730].
PHARMACEUTICAL USE: Available under the names Humulin or Humalog (Eli Lilly) and Novolin (Novo Nordisk). Used in the treatment of diabetes. Humalog is an insulin analog with 52-Lys-Pro-53 instead of 52-Pro-Lys-53.
SEQUENCE SIMILARITIES: Belongs to the insulin family.
SEQUENCE CAUTION: The sequence AAA59179.1 differs from that shown. Reason: Erroneous gene model prediction.
Molecular Weight Approx. 12 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Immunohistochemistry in human pancreas tissue.
Immunohistochemistry Analysis: 1.25 µg/mL of this antibody detected insulin in human pancreas tissue.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Store at 2-8°C and use within 1 year from date of receipt.
Packaging Information
Material Size 1 mg
Transport Information
Supplemental Information
Specifications

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