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Anti-NSD1, clone 1NW-1A10 (mouse monoclonal)

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货号：04-1565

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
R, M WB, ICC, IF, IH(P) M Ascites Monoclonal Antibody
Description
Catalogue Number 04-1565
Description Anti-NSD1 Antibody, clone 1NW-1A10
Alternate Names
  • Androgen receptor-associated coregulator 267
  • Lysine N-methyltransferase 3B
  • NR-binding SET domain-containing protein
  • Nuclear receptor-binding SET domain-containing protein 1
  • Sotos syndrome
  • nuclear receptor binding SET domain protein 1
Background Information NSD1 (also known as KMT3B) is a histone methyltransferase shown to methylate lysine 36 of histone H3 and lysine 20 of histone H4. NSD1 is a described as an intermediary transcription factor and depending on its cellular context, it is able to either negatively or positively influence transcription. Expression of this gene has been described in skeletal muscles, kidneys, adult and fetal brain, thymus and spleen. Heterozygous mutations and deletions of the NSD1 gene are associated with Sotos Syndrome, an autosomal dominant condition characterized by macrocephaly, tall stature, facial elongation, accelerated bone aging, and mental retardation.
References
Product Information
Format Ascites
Control
  • PC12 cell lysate
Presentation Unpurified mouse monoclonal IgG1κ in preservative-free ascites.
Applications
Application Anti-NSD1 Antibody, clone 1NW-1A10 is a mouse monoclonal antibody for detection of NSD1, also known as &rogen receptor-associated coregulator 267, Lysine N-methyltransferase 3B, has been validated in WB.
Key Applications
  • Western Blotting
  • Immunocytochemistry
  • Immunofluorescence
  • Immunohistochemistry (Paraffin)
Application Notes Used for immunohistochemistry on paraffin sections in Visser et al., (2012).
Used for fluorescent immunocytochemistry in Huang et al.,(1998).
Biological Information
Immunogen Recombinant protein corresponding to mouse NSD1.
Epitope Unknown
Clone clone 1NW-1A10
Host Mouse
Specificity This antibody recognizes NSD1.
Isotype IgG1κ
Species Reactivity
  • Rat
  • Mouse
Species Reactivity Note Demonstrated to react with rat. Predicted to react with mouse based on 100% sequence homology.
Antibody Type Monoclonal Antibody
Entrez Gene Number
Gene Symbol
  • NSD1
  • ARA267
  • H3-K36-HMTase
  • H4-K20-HMTase
  • KMT3B
  • SOTOS
  • STO
Purification Method Unpurified
UniProt Number
UniProt Summary FUNCTION: Histone methyltransferase. Preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4 (in vitro). Transcriptional intermediary factor capable of negatively influencing transcription. May also positively influence transcription. Essential for early post-implantation development.

CATALYTIC ACTIVITY: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.

SUBUNIT STRUCTURE: Interacts with AR DNA- and ligand-binding domains by similarity. Interacts with the ligand-binding domains of RARA and THRA in the absence of ligand; in the presence of ligand the interaction is severely disrupted but some binding still occurs. Interacts with the ligand-binding domains of RXRA and ESRRA only in the presence of ligand.

SUBCELLULAR LOCATION: Nucleus

TISSUE SPECIFICITY: Expressed in the embryo and the outer region of the uterine decidua at early post-implantation E5.5 stage. Uniformly expressed in embryonic and extraembryonic tissues during gastrulation stage E7.5. Expressed differentially after stage 14.5 with highest expression in proliferating cells. Enriched in the telencephalic region of the brain, spinal cord, intestinal crypt, tooth buds, thymus and salivary glands at stage E16.5. Also expressed in the ossification region of developing bones and in the periosteum.

DOMAIN: Contains 2 adjacent but distinct nuclear receptor interaction domains (NID+L and NID-L) to which nuclear receptors bind differentially in the presence and absence of ligand respectively.

SEQUENCE SIMILARITIES: Belongs to the histone-lysine methyltransferase family.

Contains 1 AWS domain.

Contains 4 PHD-type zinc fingers.

Contains 1 post-SET domain.

Contains 1 PWWP domain.

Contains 1 SET domain.
Molecular Weight ~ 300 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in PC12 cell lysate.

Western Blot Analysis: 1:1,000 dilution of this antibody detected NSD1 on 10 µg of PC12 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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