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Anti-Interleukin 21 (IL-21) (rabbit polyclonal)

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货号：06-1074

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, Mk, Chp FC, IH(P), WB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number 06-1074
Description Anti-Interleukin 21 (IL-21) Antibody
Alternate Names
  • Za11
  • IL-21
  • IL21
  • Interleukin-21
Background Information Interleukin 21 (IL-21) is a cytokine that has immunoregulatory activity on cells of the immune system, including natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells. IL-21 induces cell division/proliferation in its target cells and is expressed in activated human CD4+ T cells. IL-21 may promote the transition between innate and adaptive immunity and may play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. IL-21 expression is up-regulated in Th2 and Th17 subsets of T helper cells, as well as follicular T cells. Furthermore IL-21 is expressed in NK T cells regulating the function of these cells. IL-21 is also produced by Hodgkin's lymphoma (HL) cancer cells and may explain a great deal of the behavior of classical Hodgkin's lymphoma including clusters of other immune cells gathered around HL cells in cultures.
References
Product Information
Format Affinity Purified
Control
  • K562 cell lysate
Presentation Purified rabbit polyclonal in PBS with 0.06% sodium azide.
Applications
Application Anti-Interleukin 21 (IL-21) Antibody is an antibody against Interleukin 21 (IL-21) for use in FC, IH(P) & WB.
Key Applications
  • Flow Cytometry
  • Immunohistochemistry (Paraffin)
  • Western Blotting
Application Notes Flow Cytometry Analysis: 5 µg from a previous lot detected IL-21 in human PBMC's.

Immunohistochemistry Analysis: A 1:100 dilution from a previous lot detected IL-21 in mouse spleen tissue.
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to the C-terminus of human IL-21.
Epitope C-terminus
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity This antibody recognizes the C-terminus of IL-21.
Species Reactivity
  • Human
  • Mouse
  • Monkey
  • Chimpanzee
Species Reactivity Note Demonstrated to react with human and mouse.
Predicted to react with monkey and chimpanzee based on 100% sequence homology.
Cow, canine, equine, and porcine (93% sequence homology). Rat (86% sequence homology).
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • IL21
  • IL-21
Purification Method Affinity Purfied
UniProt Number
UniProt Summary FUNCTION: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG1 and IgG3 in B-cells By similarity. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.

SUBCELLULAR LOCATION: Secreted

TISSUE SPECIFICTY: Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes.

SEQUENCE SIMILARITIES: Belongs to the IL-15/IL-21 family.
Molecular Weight A molecular weight of 18 kDa was observed; however, UniProtKB/Swiss-Prot entry Q9HBE4 (IL21_HUMAN) describes 2 isoforms produced by alternative splicing: isoform 1 at 18 kDa, isoform 2 at 17 kDa.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in K562 cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected IL-21 on 10 µg of K562 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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